reduction of nitro compounds

Catalytic hydrogenation with palladium on carbon ( Pd/C) is often the method of choice for nitro reductions. The use of iron ( Fe) under acidic conditions (ex.

Common Conditions: H 2 + Pd/C.

An efficient Fe/CaCl 2 system enables the reduction of nitroarenes and reductive cleavage of azo compounds by catalytic transfer hydrogenation in the presence of sensitive functional groups including halides, carbonyl, aldehyde, acetyl, nitrile, and ester substituents with excellent yields.

The simple experimental procedure and easy purification make the protocol advantageous. ... Fe. Catalytic hydrogenation with Raney nickel effectively reduces nitro groups. H 2 + Raney Nickel.