effect on the growth of Dunning prostate cancer tumors in rats.[18]. as a cancer treatment in humans. Complementary and alternative therapies are used in an effort to prevent illness, reduce stress, prevent or reduce side effects and symptoms, or control or cure disease. Cancer Res 35 (12): 3693-7, 1975. [4,15] In Images in this summary are used with permission of the author(s), artist, and/or publisher for use within the PDQ summaries only. by all patients; and the reliance on subjective measures of quality of life more) were reported for 16 and 20 patients, respectively. Cancer patients considering complementary and alternative therapies should discuss this decision with their doctor, nurse, or pharmacist as they would any type of treatment. the synthesis of glucose. In the United States, dietary supplements are regulated as foods, not drugs. sulfate compared with patients treated with placebo was not statistically PDQ is a registered trademark. This case highlights the danger of accessing materials and medical information on the Internet and proceeding with self-medication without seeking proper medical advice and supervision. Depending on how they are used, some therapies can be considered either complementary or alternative. For additional information about levels of evidence analysis, refer to Levels of Evidence for Human Studies of Integrative, Alternative, and Complementary Therapies. activity against 13762NF mammary adenocarcinomas in rats.
Hydrazine compounds have been studied both as potential anticancer drugs Bethesda, MD: National Cancer Institute. toxic to animals and to humans, they have been administered as antidepressant (e.g., iproniazid), Anticancer Res 13 (6A): 2287-92, 1993 Nov-Dec. Kamradt JM, Pienta KJ: The effect of hydrazine sulfate on prostate cancer growth. brain) have been associated with the use of hydrazine sulfate. Tayek JA, Sutter L, Manglik S, et al. Nelson SD, Gordon WP: Metabolic activation of hydrazines. When a linked term is clicked, a definition will appear in a separate window. The FDA can, however, remove from the market dietary supplements that it deems unsafe.
Microb Pathog 13 (1): 37-47, 1992. increases in lung and liver tumors in mice,[1-4,8] and increases in liver Publications available from the FTC include: If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. The program is overseen by the NCI’s Office of Cancer Complementary and Alternative Medicine (OCCAM). Hainer MI, Tsai N, Komura ST, et al. increases in body weight associated with hydrazine sulfate use did not achieve Complete or partial regression of neurologic symptoms (e.g., seizures,
than 30 years. 2nd ed. Ann Intern Med 133 (11): 877-80, 2000. It has moderate monoamine oxidase inhibitor (MAO-I) activity (3).
nutritional status of the patients in the hydrazine sulfate group was judged : Hydrazine sulfate in cancer patients with weight loss. hydrazine sulfate has been shown to increase the incidence of several types of : Contribution of tumor necrosis factor-alpha and glucocorticoid in hydrazine sulfate-mediated protection against endotoxin lethality. regression, although the extent and duration of these regressions were not In the mid 1970s, clinical trials by a drug company found that a small number of patients who were treated with hydrazine sulfate for advanced cancer reported having a better appetite, losing less weight, feeling stronger, or having less pain. weight These preclinical studies are done before any testing in humans is begun.
Hydrazine sulfate was able to inhibit the growth of some tumors in laboratory animals when used alone or with chemotherapy drugs, but this effect has also not been shown in humans. It is intended as a resource to inform and assist clinicians who care for cancer patients. This section describes the latest [13-15] For both tumor types, enhanced after 1 to 5 months of treatment. No differences in survival, If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." growth in rats bearing Walker 256 carcinosarcoma or Murphy-Sturm lymphosarcoma tumors and in mice treatment for patients with advanced non-small cell lung cancer.
tumors in animals, and it has been classified as a potential carcinogen by the It has been suggested that cachexia occurs because the cancer is using too much of the body's sugar, preventing healthy cells from getting what they need to live. Filov VA, Gershanovich ML, Danova LA, et al. A small number of CAM therapies that were thought to be purely alternative approaches are now being used in cancer treatment—not as cures, but as complementary therapies that may help patients feel better and recover faster. Freese E, Sklarow S, Freese EB: DNA damage caused by antidepressant hydrazines and related drugs. limited evidence from animal studies suggests that hydrazine sulfate is
Johnson DC, Freudenberg MA, Jia F, et al. incidence of lung tumors in both males and females of the mouse strain C3H,
From radiation therapy to clinical trials to check-ins with your doctor, your care is made as convenient as possible. Carcinogenesis 16 (4): 801-4, 1995. Similar to other hydrazine compounds, Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. Is this therapy part of a clinical trial? females. drug combinations was reported to produce even greater antitumor effects. In addition to medicinal uses, hydrazine compounds have been used in has not been approved by the U.S. Food and Drug Administration and, thus, cannot be recommended. Hydrazine sulfate has been studied extensively in patients with advanced patients with advanced cancer. Subjective improvements in appetite, weight Complementary and alternative medicine (CAM)—also called integrative medicine—includes a broad range of healing philosophies, approaches, and therapies. experienced a complete response. In contrast with the
Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Emotional Support for Young People with Cancer, Young People Facing End-of-Life Care Decisions, Late Effects of Childhood Cancer Treatment, Tech Transfer & Small Business Partnerships, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Questions and Answers About Hydrazine Sulfate, Questions to Ask Your Health Care Provider About CAM, PDQ Integrative, Alternative, and Complementary Therapies Editorial Board, https://www.cancer.gov/about-cancer/treatment/cam/patient/hydrazine-sulfate-pdq, U.S. Department of Health and Human Services, Hydrazine sulfate may prevent the body from making sugar that cancer cells need to grow. Among the patients with glioblastomas, the Oncology 27 (1): 69-80, 1973. compounds) have been screened for their ability to kill tumors. Alcohol Alcohol Suppl 1A: 111-7, 1993. Cancer Lett 7 (6): 357-61, 1979. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. : Hydrazine sulfate in cancer patients with weight loss. The PDQ summaries are based on an independent review of the medical literature.
Procarbazine exhibited increase in average survival time was from 6 months to more than 13 sulfate was combined with the drug phloridzin, which is similar to phloretin, status or metabolic status as the primary endpoint. : Cancer: Principles and Practice of Oncology.
Hydrazine sulfate is commercially available in the United States, but it is illegal to use it as a cancer therapy. Filov VA, Gershanovich ML, Ivin BA, et al. J Natl Cancer Inst 52 (3): 903-6, 1974.
More than 400 hydrazine-related compounds have been tested for their ability to kill cancer cells. skin and/or itching, insomnia, and hypoglycemia. It has been suggested that higher-than-normal levels of TNF-alpha can cause the anorexia, increased energy
Hydrazine sulfate is a chemical used in industrial manufacturing of agricultural chemicals and rocket fuel. Shimizu H, Toth B: Effect of lifetime administration of 2-hydroxyethylhydrazine on tumorigenesis in hamsters and mice. Washington, DC: U.S. General Accounting Office, 1995, GAO-HEHS-95-141. [1,4,12,13,16,17] Clinical studies of hydrazine sulfate have been : [Therapy of primary brain tumors with segidrin] Vopr Onkol 40 (7-12): 332-6, 1994.
randomized trial involving 38 patients with advanced disease, hydrazine Furthermore, hydrazine sulfate has been shown to increase the incidence of breast, lung, and liver cancers and basal cell carcinoma.
however, was tested against only one type of tumor (Walker 256 [1] reported for 73% of the patients. To conduct clinical drug research in the United States, researchers must Lerner HJ, Regelson W: Clinical trial of hydrazine sulfate in solid tumors. Use of this Web site does not create an expressed or implied physician-patient relationship. For years the Syracuse Cancer Research Institute has known of and publicized the efficacy and safety of hydrazine sulfate in the treatment of human cancer. Gold J: Proposed treatment of cancer by inhibition of gluconeogenesis. patients could not be evaluated because of poor prognosis, missing documentation, [PMID: 26389456]. Cancer Treat Rep 60 (7): 959-60, 1976. The use of hydrazine sulfate as an anticancer drug outside the context of clinical trials
cancer. Cancer Chemother Rep 59 (6): 1151-4, 1975 Nov-Dec. Chlebowski RT, Bulcavage L, Grosvenor M, et al. than the patients who received placebo, a finding that was statistically Cancer Treat Rep 60 (7): 933-5, 1976. [24-30] Blocking gluconeogenesis and interfering with It cannot be given by the National Cancer Institute.
This is the first official notice of the efficacy of hydrazine sulfate in the treatment of human cancer. U.S. residents may call the Cancer Information Service (CIS), NCI's contact center, toll free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 9:00 am to 9:00 pm. Multiple basal cell carcinomas in a 68-year-old man following extensive exposure to hydrazine sulfate.
fatal liver and kidney failure and one case of severe encephalopathy (an injury to the Toth B: A review of the antineoplastic action of certain hydrazines and hydrazine-containing natural products. better than that of the patients in the placebo group. The patients who received hydrazine sulfate did not live longer or have their tumors shrink any more than the placebo group.
anticancer effects were observed. Vasudeva M, Vashishat RK: Mutagenic and recombinogenic activity of hydrazine sulphate in Saccharomyces cerevisiae. Board members review recently published articles each month to determine whether an article should: Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary. because of its potential as a treatment for cancer-related anorexia and PDQ is a service of the NCI. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. The preferred citation for this PDQ summary is: PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. were observed between the hydrazine sulfate group and the placebo group. Dills WL: Nutritional and physiological consequences of tumour glycolysis.
J Natl Cancer Inst 67 (3): 613-8, 1981. statistically significant differences were found between the hydrazine sulfate laboratory, hydrazine sulfate alone was found to cause dose-dependent inhibition of tumor