To evaluate the hypothesis and characterize the toxicity of CHP, male and female B6C3F1/N mice and F344/N rats were exposed to … 93.191.243.174. China Catalog of Hazardous chemicals 2015: Listed. Klapwijk A, Drent J and Steenworden J H A modified procedure for the TTC-dehydrogenase test in activated sludge. We have shown a chemopreventive effect of Myrica nagi on cumene hydroperoxide-induced cutaneous oxidative stress and toxicity in mice. We continuously strive to advance our technology. Uses. Marked exudate (arrows) on the epidermis surface of a female. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. TCI has established overseas facilities in North America, Europe, China and India to serve customers worldwide. Damage to protein synthesis concurrent with lipid peroxidation in rat liver slices: effect of halogenated compounds, peroxides, and vitamin E1. Dermal exposure to cumene hydroperoxide: Assessing its toxic relevance and oxidant potential. * Cumene Hydroperoxide may cause a skin allergy. Biosorption and Bioremediation. Cumene hydroperoxide (CHPO) is the noxious environmental pollutant whose toxicity is determined both by hydroperoxide and aromatic structures. Recommendation for cumene hydroperoxide usage levels up to: Recommendation for cumene hydroperoxide flavor usage levels up to: NIOSH International Chemical Safety Cards: Chemical Carcinogenesis Research Information System: National Institute of Allergy and Infectious Diseases: FDA Indirect Additives used in Food Contact Substances. 2000 Oct;213(1-2):99-109. doi: 10.1023/a:1007182913931. This site needs JavaScript to work properly. Fedorov A Yu, Gumenyuk A P, Volchenko E V, Korzhenevich V I and Shub G M 1994 Complex treatment of phenol production wastewaters. Abstrs Book, Czech Soc. (A82256) Completed. 2014;2014:360438. doi: 10.1155/2014/360438. Abstrs Book, p. 317. 1984 Microbial Degradation of Organic Compounds. Determination of total plasma hydroperoxides using a diphenyl-1-pyrenylphosphine fluorescent probe. Buchanan and Gibbons (Eds.) Biochem. 592 (in Russian). Note the hyperplastic sebaceous glands (curved arrows). Miller J H 1976 Experiments in molecular genetics. The preferred peroxides include, ), and alkyl hydroperoxides (ROOH) such as, Thiol Redox Transitions in Cell Signaling, Part B: Cellular Localization and Signaling, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Mutation Research/Genetic Toxicology and Environmental Mutagenesis. Dose: R&M: 0, 0.75, 1.5, 3, 6, or 12 mg/kg; R: 20/sex/dose; M: 10/sex/dose. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. 2016 Jul;44(5):749-762. Mir, Moscow pp. Before sharing sensitive information, make sure you're on a federal government site. Technol. SigmaB activation under environmental and energy stress conditions in Listeria monocytogenes. 536. No significant changes in survival or body weight of mice and rats were observed following 14 days of exposure. Cumene hydroperoxide treatment at a dose level of 30 mg/animal/0.2 ml acetone enhances susceptibility of cutaneous microsomal membrane for iron-ascorbate-induced lipid peroxidation and induction of xanthine oxidase activity which are accompanied by decrease in the activities of cutane… Download preview PDF. When determining an apparent Km in a Lineweaver−Burk plot in the presence of 4 to 200 µM H2O2, a Km value of 10 µM is determined in the presence of 5 µM PfTrx, a value of 17 µM is determined in the presence of 10 µM PfTrx, and 41 µM in the presence of 20 µM PfTrx. PubMed:Iron-accelerated cumene hydroperoxide decomposition in hexadecane and trilaurin emulsions. Toxicity of linoleic acid hydroperoxide to Saccharomyces cerevisiae: involvement of a respiration-related process for maximal sensitivity and adaptive response. Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica. Biochem. In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS. Homologous overexpression of alkyl hydroperoxide reductase subunit C (ahpC) protects Bifidobacterium longum strain NCC2705 from oxidative stress. Natl Toxicol Program Tech Rep Ser. The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells. The protective effect of Myrica nagi was dose-dependent. In conclusion, topical CHP application caused skin damage only at the application site and did not cause systemic tissue impairment. 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies). | Int. 20% Aromatic Hydrocarbon), FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS, Atomic Weights of the Elements 2011 (pdf). In ECB 6. Biodeterior. We use cookies to help provide and enhance our service and tailor content and ads. Epidermal hyperplasia (long arrows) and sebaceous gland hyperplasia (short arrows) in a male rat. Environ. Ability of surfactant headgroup size to alter lipid and antioxidant oxidation in oil-in-water emulsions. Necrosis of the superficial epidermis characterized by hypereosinophilia and loss of cellular detail (arrows). 29, 163–166. Get the latest research from NIH: https://www.nih.gov/coronavirus. Of particular interest is the unique direct coupling to NADPH by the mammalian enzyme without any soluble intermediates. An official website of the United States government. 2010, 132(16), 5886–5895, with permission from American Chemical Society. 1D. Note epidermal hyperplasia and sebaceous gland hyperplasia. Odor and/or flavor descriptions from others (if found). Violent reaction occurs upon contact with copper, copper alloys, lead alloys, and mineral acids. 32. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Cumene hydroperoxide (CHP) is a high production volume chemical that is used to generate phenol and acetone. Ergosterol oxidation may be considered a signal for fungal growth and aflatoxin production in Aspergillus parasiticus. Note inflammatory cells throughout the dermis. In summary our data suggest that Myrica nagi is an effective chemopreventive agent in skin and capable of ameliorating cumene hydroperoxide-induced cutaneous oxidative stress and toxicity.